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In the design of an automatic transmission gearbox, the variation of one parameter can result in different system performances due to the strong interdependencies among all components. For given transmission ratios, component lifetimes and safeties, or space restrictions, improvements in efficiency, noise, and weight can be achieved.
After decades of iteration, you might think manufacturing software suites are running out of new modules to add, but improving hardware is opening up new avenues for them to explore.
Microgears for some types of medical technology need to be inexpensively mass produced. But at the same time, they need to be both precise and reliable, even though their design lifetime is relatively short. Here's how microgears were developed for blood glucose measuring devices, insulin pumps for diabetics and other very small devices.